General Information:

Id: 1,333 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Robakis NK(2011) Mechanisms of AD neurodegeneration may be independent of Abeta and its derivatives Neurobiol. Aging 32: 372-379 [PMID: 20594619]

Interaction Information:

Comment PSs have gamma-secretase-independent functions including stimulation of the PI3K/Akt and MEK/ERK cell survival signaling, regulation of the glycogen synthase kinase-3 and calcium homeostasis.
Formal Description
Interaction-ID: 9185

gene/protein

PSEN1

increases_activity of

process

PI3K/AKT signaling

Comment PSs have gamma-secretase-independent functions including stimulation of the PI3K/Akt and MEK/ERK cell survival signaling, regulation of the glycogen synthase kinase-3 and calcium homeostasis.
Formal Description
Interaction-ID: 9187

gene/protein

PSEN1

increases_activity of

process

MEK/ERK signaling

Comment PSs have gamma-secretase-independent functions including stimulation of the PI3K/Akt and MEK/ERK cell survival signaling, regulation of the glycogen synthase kinase-3 and calcium homeostasis.
Formal Description
Interaction-ID: 9188

gene/protein

PSEN1

affects_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment PSs have gamma-secretase-independent functions including stimulation of the PI3K/Akt and MEK/ERK cell survival signaling, regulation of the glycogen synthase kinase-3 and calcium homeostasis.
Formal Description
Interaction-ID: 9189

gene/protein

PSEN1

affects_activity of