General Information:

Id: 1,323
Diseases: Disease-related-protein CtBP
Mammalia
article
Reference: Zhang Q et al.(2003) Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP Cell 115: 177-186 [PMID: 14567915]

Interaction Information:

Comment HIPK2 is a CtBP2-interacting protein.
Formal Description
Interaction-ID: 9057

gene/protein

HIPK2

interacts (colocalizes) with

gene/protein

CTBP2

Comment Phosphorylation by HIPK2 targets CtBP to a proteasomal degradation pathway. The resultant decrease in CtBP levels, like the HIPK2 activation of p53, sensitizes cells to apoptosis.
Formal Description
Interaction-ID: 9060

decreases_quantity of

gene/protein

CTBP2

after UV-stress
Comment Phosphorylation by HIPK2 targets CtBP to a proteasomal degradation pathway. The resultant decrease in CtBP levels, like the HIPK2 activation of p53, sensitizes cells to apoptosis.
Formal Description
Interaction-ID: 9061

gene/protein

HIPK2

increases_phosphorylation of

gene/protein

CTBP2

after UV-stress
Comment Phosphorylation by HIPK2 targets CtBP to a proteasomal degradation pathway. The resultant decrease in CtBP levels, like the HIPK2 activation of p53, sensitizes cells to apoptosis.
Formal Description
Interaction-ID: 9062

gene/protein

HIPK2

decreases_quantity of

gene/protein

CTBP2

by targeting CtBP2 to the proteasomal degradation pathway
Comment CtBP2 is antiapoptotic.
Formal Description
Interaction-ID: 9063

gene/protein

CTBP2

decreases_activity of