General Information:

Id: 1,319 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
GFAP-Nrf2/ARE-hPAP mouse
BTO:0001279 spinal cord; BTO:0003852 astroglia
Reference: Vargas MR et al.(2008) Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis J. Neurosci. 28 [PMID: 19074031]

Interaction Information:

Comment Nrf2 over-expression in the spinal cord increased transcription of prototypical ARE-driven genes, including NQO1, heme oxygenase-1 (HO-1), GCL modifier (GCLM) and catalytic subunit (GCLC). GCL is the rate-limiting enzyme for glutathione synthesis.
Formal Description
Interaction-ID: 9023



affects_quantity of

drug/chemical compound


Drugbank entries Show/Hide entries for GCLM or Glutathione