General Information:

Id: 1,319 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
GFAP-Nrf2/ARE-hPAP mouse
BTO:0001279 spinal cord; BTO:0003852 astroglia
article
Reference: Vargas MR et al.(2008) Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis J. Neurosci. 28 [PMID: 19074031]

Interaction Information:

Comment Increased mRNA expression of Nrf2 and ARE-driven genes in GFAP-Nrf2 spinal cord astrocytes increased glutathione secretion and resistance to oxidative stress.
Formal Description
Interaction-ID: 9015

gene/protein

NFE2L2

increases_quantity of

drug/chemical compound

Glutathione

if Nrf2 is overexpressed
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