General Information:

Id: 1,315
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
THP-1 monocytes
article
Reference: Wilkinson BL et al.(2012) Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimers disease Neurobiol. Aging 33: 197 [PMID: 20696495]

Interaction Information:

Comment Ibuprofen inhibited fAbeta-stimulated Vav phosphorylation in THP-1 cells.
Formal Description
Interaction-ID: 9000

drug/chemical compound

Ibuprofen

decreases_phosphorylation of

gene/protein

VAV1

in THP-1 cells; induced by fibrillar Abeta-stimulation
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Comment S-ibuprofen disrupted downstream signaling to NOX2 (NADPH oxidase) complex assembly.
Formal Description
Interaction-ID: 9001

drug/chemical compound

Ibuprofen

decreases_activity of

process

signaling

signaling disruption to NOX2 (NADPH oxidase) complex assembly
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Comment S-ibuprofen impairs NOX2 complex assembly.
Formal Description
Interaction-ID: 9003

drug/chemical compound

Ibuprofen

decreases_activity of

impairment of NOX2 complex assembly
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Comment S-ibuprofen pretreatment of THP-1 cells leads to a dose-dependent inhibition of fAbeta-mediated Rac translocation to the plasma membrane, thus preventing its interaction with other NOX2 enzyme components and preventing an assembly to the catalytically active oxidase.
Formal Description
Interaction-ID: 9029

drug/chemical compound

Ibuprofen

decreases transport of

gene/protein

RAC1

to plasma membrane; inhibition of fibrillar Abeta-mediated Rac translocation to the plasma membrane
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Comment S-ibuprofen pretreatment decreases Abeta-induced MAPK14 (p38) activity.
Formal Description
Interaction-ID: 9030

drug/chemical compound

Ibuprofen

decreases_activity of

gene/protein

MAPK14

Abeta-induced MAPK14 (p38) activity
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