General Information:

Id: 1,315 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
THP-1 monocytes
article
Reference: Wilkinson BL et al.(2012) Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimers disease Neurobiol. Aging 33: 197 [PMID: 20696495]

Interaction Information:

Comment S-ibuprofen pretreatment of THP-1 cells leads to a dose-dependent inhibition of fAbeta-mediated Rac translocation to the plasma membrane, thus preventing its interaction with other NOX2 enzyme components and preventing an assembly to the catalytically active oxidase.
Formal Description
Interaction-ID: 9029

drug/chemical compound

Ibuprofen

decreases transport of

gene/protein

RAC1

to plasma membrane; inhibition of fibrillar Abeta-mediated Rac translocation to the plasma membrane
Drugbank entries Show/Hide entries for Ibuprofen or RAC1