CIDeRGeneral Information:
| Id: | 1,311 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| male | |
| ob/ob mouse | |
| article | |
| Reference: | Ozcan U et al.(2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 5790: 1137-1140 [PMID: 16931765] |
Interaction Information:
| Comment | In both PBA- and TUDCA-treated mice, glucose uptake in muscle and adipose tissue was increased compared to that in tissues from vehicle-treated control animals. |
|
Formal Description Interaction-ID: 8990 |
drug/chemical compound increases_activity of process |
| Comment | In both PBA- and TUDCA-treated mice, glucose uptake in muscle and adipose tissue was increased compared to that in tissues from vehicle-treated control animals. |
|
Formal Description Interaction-ID: 8991 |
drug/chemical compound increases_activity of process |
| Comment | In mice treated with TUDCA, a bile acid derivative that diminishes ER stress responses, glucose uptake in muscle and adipose tissue was increased compared to that in tissues from vehicle-treated control animals. |
|
Formal Description Interaction-ID: 72606 |
increases_activity of process |