General Information:

Id: 1,311 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
ob/ob mouse
Reference: Ozcan U et al.(2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 5790: 1137-1140 [PMID: 16931765]

Interaction Information:

Comment Biochemical indicators of ER stress and major elements of IR signal transduction pathway were examined in liver and adipose tissues of TUDCA-treated mice and controls. TUDCA-treated ob/ob mice showed suppression of obesity-induced PERK and IRE-1alpha phosphorylation and JNK activation in the liver and adipose tissues. Serine phosphorylation of IRS-1, which negatively regulates insulin receptor signaling, was also suppressed in liver tissues of TUDCA-treated ob/ob mice compared to vehicle-treated controls. Consistent with these changes, there was a marked recovery of insulin receptor signaling capacity in TUDCA-treated ob/ob mice. In liver and adipose tissues, acute insulin stimulation failed to induce IR, IRS-1, IRS-2, and Akt phosphorylations in vehicle-treated ob/ob mice compared to their lean controls, and TUDCA treatment restored the insulin signaling capacity in both tissue.
Formal Description
Interaction-ID: 8986

drug/chemical compound

Tauroursodeoxycholic acid

increases_activity of

in obese mice