General Information:

Id: 1,311 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
ob/ob mouse
Reference: Ozcan U et al.(2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 5790: 1137-1140 [PMID: 16931765]

Interaction Information:

Comment If the reversal of hyperglycemia, increased glucose tolerance, and insulin sensitivity are related to decreased ER stress, PBA-treated ob/ob mice should display a reduction in indicators of ER stress. In PBA treated ob/ob mice, PERK and IRE-1alpha phosphorylation in liver was markedly reduced in comparison with vehicle-treated ob/ob controls. Similar results were also observed in adipose tissue of PBA-treated ob/ob mice.
Formal Description
Interaction-ID: 8957

drug/chemical compound

Sodium phenylbutyrate

decreases_activity of

in liver, in adipose tissue
Comment Tauroursodeoxycholic acid (TUDCA) suppresses tunicamycin-induced ER stress in Fao liver cells.
Formal Description
Interaction-ID: 72603

drug/chemical compound

Tauroursodeoxycholic acid

decreases_activity of

in liver
Comment In mice treated with TUDCA, a bile acid derivative that diminishes ER stress responses, glucose uptake in muscle and adipose tissue was increased compared to that in tissues from vehicle-treated control animals.
Formal Description
Interaction-ID: 72606

increases_activity of


glucose import

in liver, in adipose tissue; via decreasing ER stress