General Information:

Id: 1,311 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
ob/ob mouse
Reference: Ozcan U et al.(2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 5790: 1137-1140 [PMID: 16931765]

Interaction Information:

Comment In mice treated with TUDCA, a bile acid derivative that diminishes ER stress responses, glucose uptake in muscle and adipose tissue was increased compared to that in tissues from vehicle-treated control animals.
Formal Description
Interaction-ID: 72606

increases_activity of


glucose import

in liver, in adipose tissue; via decreasing ER stress