General Information:

Id: 1,310 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
Embryonic motoneurons isolated from E12.5 wild-type mice or mice overexpressing the G85R mutant form of SOD1 (SOD1G85R)
BTO:0000312 motoneuron
Reference: Duplan L et al.(2010) Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death J. Neurosci. 30: 785-796 [PMID: 20071543]

Interaction Information:

Comment Immunostaining showed that exposure to NO (nitric oxide) in vitro induced an increase in CRMP4a, but not CRMP2 (DPYSL2), in mutant SOD1 motoneurons, but not controls.
Formal Description
Interaction-ID: 8951

drug/chemical compound


NOT increases_quantity of



in mutant SOD1G85R mice