CIDeRGeneral Information:
| Id: | 1,306 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| BTO:0001517 FAO cell | |
| article | |
| Reference: | Ozcan U et al.(2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306: 457-461 [PMID: 15486293] |
Interaction Information:
| Comment | ER stress inhibits insulin action in liver cells, ER stress promotes a JNK-dependent serine phosphorylation of IRS-1, which in turn inhibits insulin receptor signaling. |
|
Formal Description Interaction-ID: 8918 |
decreases_activity of |
| Comment | ER stress inhibits insulin action in liver cells, ER stress promotes a JNK-dependent serine phosphorylation of IRS-1, which in turn inhibits insulin receptor signaling. |
|
Formal Description Interaction-ID: 8922 |
|
| Drugbank entries | Show/Hide entries for MAPK8 |