General Information:

Id: 1,306 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
BTO:0001517 FAO cell
article
Reference: Ozcan U et al.(2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306: 457-461 [PMID: 15486293]

Interaction Information:

Comment ER stress inhibits insulin action in liver cells, ER stress promotes a JNK-dependent serine phosphorylation of IRS-1, which in turn inhibits insulin receptor signaling.
Formal Description
Interaction-ID: 8918

decreases_activity of

in liver
Comment ER stress inhibits insulin action in liver cells, ER stress promotes a JNK-dependent serine phosphorylation of IRS-1, which in turn inhibits insulin receptor signaling.
Formal Description
Interaction-ID: 8922

increases_activity of

gene/protein

MAPK8

in liver
Drugbank entries Show/Hide entries for MAPK8