General Information:

Id: 1,304
Diseases: Disease-related-protein CtBP
Homo sapiens
BTO:0002254 HCT-116 cell, p53-/-; BTO:0002552 NCI-H1299 cell; BTO:0001938 U2-OS cell
article
Reference: Kovi RC et al.(2010) An ARF/CtBP2 complex regulates BH3-only gene expression and p53-independent apoptosis Cell Death Differ. 17: 513-521 [PMID: 19798104]

Interaction Information:

Comment Bik expression was increased upon either CtBP2 depletion (2.6-fold) or ARF overexpression (2.3-fold) in HCT116 p53-/- cells. CtBP2 is recruited to the Bik promoter largely through interaction with BKLF.
Formal Description
Interaction-ID: 8901

gene/protein

CTBP2

decreases_expression of

gene/protein

BIK

in the presence of BKLF
Comment Bik expression was increased upon either CtBP2 depletion (2.6-fold) or ARF overexpression (2.3-fold) in HCT116 p53-/- cells. Interaction between CtBP and ARF is necessary for the ARF-dependent regulation of Bik.
Formal Description
Interaction-ID: 8902

gene/protein

CDKN2A

increases_expression of

gene/protein

BIK

CtBP2 interaction is required for ARF regulation of Bik
Comment CtBP2 is recruited to the Bik promoter largely through interaction with BKLF.
Formal Description
Interaction-ID: 8903

gene/protein

CTBP2

interacts (colocalizes) with

gene/protein

KLF3

Comment After knockdown of CtBP2, the expression of the BH3-only proapoptotic genes Bik, Bim, Bmf, Puma and Noxa was induced.
Formal Description
Interaction-ID: 8909

gene/protein

CTBP2

decreases_expression of

gene/protein

BCL2L11

Comment After knockdown of CtBP2, the expression of the BH3-only proapoptotic genes Bik, Bim, Bmf, Puma and Noxa was induced.
Formal Description
Interaction-ID: 8911

gene/protein

CTBP2

decreases_expression of

gene/protein

BMF

Comment After knockdown of CtBP2, the expression of the BH3-only proapoptotic genes Bik, Bim, Bmf, Puma and Noxa was induced.
Formal Description
Interaction-ID: 8912

gene/protein

CTBP2

decreases_expression of

gene/protein

BBC3

Comment After knockdown of CtBP2, the expression of the BH3-only proapoptotic genes Bik, Bim, Bmf, Puma and Noxa was induced.
Formal Description
Interaction-ID: 8913

gene/protein

CTBP2

decreases_expression of

gene/protein

PMAIP1

Comment After knockdown of CtBP2, the expression of the BH3-only proapoptotic genes Bik, Bim, Bmf, Puma and Noxa was induced.
Formal Description
Interaction-ID: 8914

gene/protein

BCL2L11

increases_activity of

Comment After knockdown of CtBP2, the expression of the BH3-only proapoptotic genes Bik, Bim, Bmf, Puma and Noxa was induced.
Formal Description
Interaction-ID: 8915

gene/protein

BMF

increases_activity of

Comment After knockdown of CtBP2, the expression of the BH3-only proapoptotic genes Bik, Bim, Bmf, Puma and Noxa was induced.
Formal Description
Interaction-ID: 8916

gene/protein

BBC3

increases_activity of

Comment After knockdown of CtBP2, the expression of the BH3-only proapoptotic genes Bik, Bim, Bmf, Puma and Noxa was induced.
Formal Description
Interaction-ID: 8917

gene/protein

PMAIP1

increases_activity of

Comment An analysis of the Bik promoter revealed binding sites for the CtBP-interacting basic Kruppel-like factor (BKLF). A Bik promoter luciferase reporter was repressed by BKLF and CtBP2, and ARF reversed CtBP-associated repression.
Formal Description
Interaction-ID: 8919

gene/protein

KLF3

decreases_expression of

gene/protein

BIK

via recruiting CtBP2 to the Bik promoter
Comment After knockdown of CtBP2, the expression of the BH3-only proapoptotic genes Bik, Bim, Bmf, Puma and Noxa was induced.
Formal Description
Interaction-ID: 8926

gene/protein

CTBP2

decreases_activity of