General Information:

Id: 12 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Rattus norvegicus
BTO:0000991 pancreatic islet
article
Reference: Lee JH et al.(2009) Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes 58: 344-351 [PMID: 19008341]

Interaction Information:

Comment Pretreatment with resveratrol or SIRT1 overexpression blocked the effect of the cytokine and restored islet cell insulin secretion to the control level.
Formal Description
Interaction-ID: 46

gene/protein

SIRT1

increases_activity of

if SIRT1 is overexpressed in cytokine treated cells
Comment Pretreatment with resveratrol or SIRT1 overexpression blocked the effect of the cytokine and restored islet cell insulin secretion to the control level.
Formal Description
Interaction-ID: 48

drug/chemical compound

Resveratrol

increases_activity of

in cytokine treated cells
Drugbank entries Show/Hide entries for Resveratrol
Comment Cytokine treatment significantly decreased insulin secretion in rat islets.
Formal Description
Interaction-ID: 61

gene/protein

IL1B

decreases_activity of

in rat islets
Drugbank entries Show/Hide entries for IL1B