General Information:

Id: 12 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Rattus norvegicus
BTO:0000991 pancreatic islet
article
Reference: Lee JH et al.(2009) Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes 58: 344-351 [PMID: 19008341]

Interaction Information:

Comment Pretreatment with resveratrol or SIRT1 overexpression blocked the effect of the cytokine and restored islet cell insulin secretion to the control level.
Formal Description
Interaction-ID: 46

gene/protein

SIRT1

increases_activity of

process

insulin secretion

if SIRT1 is overexpressed in cytokine treated cells