General Information:
Id: | 12 (click here to show other Interactions for entry) |
Diseases: |
Diabetes mellitus, type I
- [OMIM]
|
Rattus norvegicus | |
BTO:0000991 pancreatic islet | |
article | |
Reference: | Lee JH et al.(2009) Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes 58: 344-351 [PMID: 19008341] |
Interaction Information:
Comment | Pretreatment with resveratrol or SIRT1 overexpression blocked the effect of the cytokine and restored islet cell insulin secretion to the control level. |
Formal Description Interaction-ID: 46 |
gene/protein increases_activity of process |