General Information:

Id: 1,299 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
article
Reference: Ozcan U et al.(2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306: 457-461 [PMID: 15486293]

Interaction Information:

Comment The pancreatic ER kinase or PKR-like kinase (PERK) is an ER transmembrane protein kinase that phosphorylates the alpha subunit of translation initiation factor 2 (eIF2-alpha) in response to ER stress. The phosphorylation status of PERK and eIF2-alpha is therefore a key indicator of the presence of ER stress. Determination of the phosphorylation status demonstrated increased PERK and eIF2-alpha phosphorylation in liver extracts of obese mice compared with lean controls. As in liver, PERK phosphorylation was significantly increased in adipose tissue.
Formal Description
Interaction-ID: 8883

disease

Obesity

increases_activity of

in liver, in adipose tissue
Comment Alterations in the levels of cellular XBP-1s protein, the spliced or processed form of XBP-1, result in alterations in the ER stress responses.
Formal Description
Interaction-ID: 8930

gene/protein

XBP1

affects_activity of