General Information:

Id: 1,292 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Hevener AL et al.(2007) Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones J. Clin. Invest. 117: 1658-1669 [PMID: 17525798]

Interaction Information:

Comment Macrophage-specific PPAR-gamma deletion causes susceptibility to high fat diet-induced insulin resistance and diminished thiazolidinedione effectiveness.
Formal Description
Interaction-ID: 8814

gene/protein

PPARG

affects_activity of

drug/chemical compound

Thiazolidinedione

after myeloid-specific PPARG deletion, after high-fat diet-induced insulin resistance
Drugbank entries Show/Hide entries for PPARG