General Information:

Id: 1,292 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Hevener AL et al.(2007) Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones J. Clin. Invest. 117: 1658-1669 [PMID: 17525798]

Interaction Information:

Comment The effect of macrophage-specific PPAR-gamma knockout on insulin signaling in skeletal muscle and liver was a significant reduction in insulin-stimulated tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1) along with a corresponding decrease in serine phosphorylation of Akt in both tissues. Reductions in IRS-1 and Akt phosphorylation in muscle and liver were paralleled by significant increases in the activation of IKK-alpha/beta (phospho-IKK) and JNK (phospho-JNK), serine kinases previously shown to cause inhibition of IRS-1 function and insulin signaling.
Formal Description
Interaction-ID: 8785



affects_activity of

in liver, in skeletal muscle; after myeloid-specific PPARG deletion
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