CIDeRGeneral Information:
| Id: | 1,292 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| male | |
| article | |
| Reference: | Hevener AL et al.(2007) Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones J. Clin. Invest. 117: 1658-1669 [PMID: 17525798] |
Interaction Information:
| Comment | The effect of macrophage-specific PPAR-gamma knockout on insulin signaling in skeletal muscle and liver was a significant reduction in insulin-stimulated tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1) along with a corresponding decrease in serine phosphorylation of Akt in both tissues. Reductions in IRS-1 and Akt phosphorylation in muscle and liver were paralleled by significant increases in the activation of IKK-alpha/beta (phospho-IKK) and JNK (phospho-JNK), serine kinases previously shown to cause inhibition of IRS-1 function and insulin signaling. |
|
Formal Description Interaction-ID: 8785 |
gene/protein affects_activity of |
| Drugbank entries | Show/Hide entries for PPARG |