General Information:

Id: 1,265
Diseases: Parkinson disease
Mus musculus
FVB mouse
BTO:0001311 corpus striatum
article
Reference: Chen X et al.(2008) Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum J. Neurochem. 4: 1147-1157 [PMID: 18808450]

Interaction Information:

Comment Caffeine attenuated MPTP-induced loss of dopaminergic neuron in striatum.
Formal Description
Interaction-ID: 8562

increases_activity of

process

neuron death

in striatum
Comment Caffeine attenuated MPTP-induced gliosis (activation of microglial cells and astrocytes) in striatum.
Formal Description
Interaction-ID: 8580

increases_activity of

process

glia cell activation

in striatum
Comment Caffeine attenuated MPTP-induced loss of dopaminergic neuron in striatum.
Formal Description
Interaction-ID: 8581

drug/chemical compound

Caffeine

decreases_activity of

process

neuron death

in striatum; after MPTP treatment
Drugbank entries Show/Hide entries for Caffeine
Comment Caffeine attenuated MPTP-induced loss of dopaminergic neuron in striatum.
Formal Description
Interaction-ID: 8582

drug/chemical compound

Caffeine

decreases_activity of

in striatum
Drugbank entries Show/Hide entries for Caffeine
Comment Caffeine attenuated MPTP-induced gliosis (activation of microglial cells and astrocytes) in striatum.
Formal Description
Interaction-ID: 8583

drug/chemical compound

Caffeine

decreases_activity of

process

glia cell activation

in striatum; after MPTP treatment
Drugbank entries Show/Hide entries for Caffeine
Comment Caffeine attenuated MPTP-induced gliosis (activation of microglial cells and astrocytes) in striatum.
Formal Description
Interaction-ID: 8584

process

glia cell activation

increases_activity of

Comment Caffeine attenuated MPTP-induced gliosis (activation of microglial cells and astrocytes) in striatum.
Formal Description
Interaction-ID: 8585

process

glia cell activation

increases_activity of

Comment Caffeine blocked MPTP-induced leakage of the BBB in striatum.
Formal Description
Interaction-ID: 8586

drug/chemical compound

Caffeine

increases_activity of

in striatum; after MPTP treatment
Drugbank entries Show/Hide entries for Caffeine
Comment Caffeine blocked MPTP-induced leakage of the BBB in striatum.
Formal Description
Interaction-ID: 8587

decreases_activity of

in striatum
Comment MPTP treatment decreased significantly the protein levels of both ZO-1 and occludin in striatum, and these effects were blocked by caffeine. Caffeine treatment alone had no effect on the protein levels of these two tight junction proteins.
Formal Description
Interaction-ID: 8588

decreases_quantity of

gene/protein

TJP1

in striatum
Comment MPTP treatment decreased significantly the protein levels of both ZO-1 and occludin in striatum, and these effects were blocked by caffeine. Caffeine treatment alone had no effect on the protein levels of these two tight junction proteins.
Formal Description
Interaction-ID: 8589

decreases_quantity of

gene/protein

OCLN

in striatum
Comment MPTP treatment decreased significantly the protein levels of both ZO-1 and occludin in striatum, and these effects were blocked by caffeine. Caffeine treatment alone had no effect on the protein levels of these two tight junction proteins.
Formal Description
Interaction-ID: 8590

drug/chemical compound

Caffeine

increases_quantity of

gene/protein

TJP1

in striatum; after MPTP treatment
Drugbank entries Show/Hide entries for Caffeine
Comment MPTP treatment decreased significantly the protein levels of both ZO-1 and occludin in striatum, and these effects were blocked by caffeine. Caffeine treatment alone had no effect on the protein levels of these two tight junction proteins.
Formal Description
Interaction-ID: 8591

drug/chemical compound

Caffeine

increases_quantity of

gene/protein

OCLN

in striatum; after MPTP treatment
Drugbank entries Show/Hide entries for Caffeine
Comment MPTP treatment decreased significantly the protein levels of both ZO-1 and occludin in striatum, and these effects were blocked by caffeine. Caffeine treatment alone had no effect on the protein levels of these two tight junction proteins.
Formal Description
Interaction-ID: 8592

gene/protein

TJP1

increases_activity of

Comment MPTP treatment decreased significantly the protein levels of both ZO-1 and occludin in striatum, and these effects were blocked by caffeine. Caffeine treatment alone had no effect on the protein levels of these two tight junction proteins.
Formal Description
Interaction-ID: 8593

gene/protein

OCLN

increases_activity of

Comment MPTP significantly increased mRNA levels of MMP9 in striatum, and this effect was blocked by caffeine.
Formal Description
Interaction-ID: 8598

increases_expression of

gene/protein

MMP9

in striatum
Comment MPTP significantly increased mRNA levels of MMP9 in striatum, and this effect was blocked by caffeine.
Formal Description
Interaction-ID: 8600

drug/chemical compound

Caffeine

decreases_expression of

gene/protein

MMP9

in striatum; after MPTP treatment
Drugbank entries Show/Hide entries for Caffeine
Comment Caffeine attenuated MPTP-induced loss of dopaminergic neuron in striatum.
Formal Description
Interaction-ID: 8614

drug/chemical compound

Caffeine

increases_activity of

process

neuroprotection

in striatum; after MPTP treatment
Drugbank entries Show/Hide entries for Caffeine