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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	124 (click here to show other Interactions for entry)
Diseases:	Amyotrophic lateral sclerosis
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0001279 spinal cord
Publication type:	article
Reference:	Hetz C et al.(2009) XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev. 23: 2294-2306 [PMID: 19762508]

Interaction Information:

Comment	Human post-mortem spinal cord samples of sALS and fALS cases displayed a marked activation of both the UPR and autophagy.
Formal Description Interaction-ID: 430	disease Amyotrophic lateral sclerosis increases_activity of process autophagy

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