General Information:

Id: 123 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G86R) transgenic mouse
BTO:0001279 spinal cord
article
Reference: Hetz C et al.(2009) XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy Genes Dev. 23: 2294-2306 [PMID: 19762508]

Interaction Information:

Comment The increase in autophagy in SOD1 mutant spinal cords is significantly enhanced, when XBP-1 is ablated in the nervous system.
Formal Description
Interaction-ID: 429

gene/protein

XBP1

affects_activity of

process

autophagy