General Information:

Id: 1,232 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
male
article
Reference: Mamane Y et al.(2009) The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation Diabetes 58: 2006-2017 [PMID: 19581423]

Interaction Information:

Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8408

gene/protein

C3AR1

NOT affects_quantity of

gene/protein

IL6

after high-fat diet
Drugbank entries Show/Hide entries for IL6