General Information:

Id: 1,232
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
male
article
Reference: Mamane Y et al.(2009) The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation Diabetes 58: 2006-2017 [PMID: 19581423]

Interaction Information:

Comment C3aR mRNA expression was increased 13-fold in the epididymal white adipose tissue (eWAT) from mice on high fat diet (HFD). Subfractionation of the eWAT into adipocyte fraction and stromal vascular cell (SVC) fraction (mainly macrophages and preadipocytes) revealed that C3aR expression was significantly overexpressed in both fractions.
Formal Description
Interaction-ID: 8269

environment

high-fat diet

increases_expression of

gene/protein

C3AR1

in epididymal white adipose tissue; 13-fold increase
Comment C3aR expression was significantly increased in brown adipose tissue (BAT) (sixfold) from mice on high fat diet.
Formal Description
Interaction-ID: 8270

environment

high-fat diet

increases_expression of

gene/protein

C3AR1

in brown adipose tissue; sixfold increase
Comment A twofold increase in C3aR expression was also seen in muscle from mice on high fat diet.
Formal Description
Interaction-ID: 8271

environment

high-fat diet

increases_expression of

gene/protein

C3AR1

in muscle; twofold increase
Comment No increase in C3aR expression was seen in the liver, brain, or pancreas of mice on high fat diet.
Formal Description
Interaction-ID: 8272

environment

high-fat diet

NOT increases_expression of

gene/protein

C3AR1

in liver, in pancreas, in brain
Comment C3aR-/- mice had improved insulin sensitivity on both normal diet and high fat diet as seen by an insulin tolerance test and an oral glucose tolerance test.
Formal Description
Interaction-ID: 8273

gene/protein

C3AR1

affects_activity of

disease

Insulin resistance

after normal diet, after high-fat diet
Comment C3aR-/- on both normal diet and high fat diet had a significant reduction in liver triglyceride levels compared with wild type. Liver histology confirmed that the C3aR-/- mice on both normal diet and high fat diet had significantly less lipid accumulation compared with wild type.
Formal Description
Interaction-ID: 8327

gene/protein

C3AR1

affects_quantity of

drug/chemical compound

Triacylglycerol

in liver; after high-fat diet
Comment C3aR-/- mice are protected from HFD-induced liver steatosis.
Formal Description
Interaction-ID: 8334

gene/protein

C3AR1

affects_activity of

disease

Fatty liver disease, nonalcoholic

after high-fat diet
Comment An increased IR-beta chain and AKT phosphorylation and thus activation was seen in both the liver and epididymal white adipose tissue of lean C3aR-/- mice upon insulin challenge compared with wild type (2- to 2.5-fold increase).
Formal Description
Interaction-ID: 8335

gene/protein

C3AR1

affects_phosphorylation of

in liver, in epididymal white adipose tissue; after insulin challange, in lean mice
Comment An increased IR-beta chain and AKT phosphorylation and thus activation was seen in both the liver and epididymal white adipose tissue of lean C3aR-/- mice upon insulin challenge compared with wild type (2- to 2.5-fold increase).
Formal Description
Interaction-ID: 8336

gene/protein

C3AR1

affects_phosphorylation of

gene/protein

AKT1

in liver, in epididymal white adipose tissue; after insulin challange, in lean mice
Drugbank entries Show/Hide entries for AKT1
Comment An increased IR-beta chain and AKT phosphorylation and thus activation was seen in both the liver and epididymal white adipose tissue of lean C3aR-/- mice upon insulin challenge compared with wild type (2- to 2.5-fold increase).
Formal Description
Interaction-ID: 8337

gene/protein

C3AR1

affects_activity of

in liver, in epididymal white adipose tissue; after insulin challange, in lean mice
Comment An increased IR-beta chain and AKT phosphorylation and thus activation was seen in both the liver and epididymal white adipose tissue of lean C3aR-/- mice upon insulin challenge compared with wild type (2- to 2.5-fold increase).
Formal Description
Interaction-ID: 8338

gene/protein

C3AR1

affects_activity of

gene/protein

AKT1

in liver, in epididymal white adipose tissue; after insulin challange, in lean mice
Drugbank entries Show/Hide entries for AKT1
Comment An increased AKT phosphorylation was seen in the liver and eWAT of C3aR-/- mice on HFD upon insulin challenge compared with wild type (5.6- and 2-fold increase).
Formal Description
Interaction-ID: 8339

gene/protein

C3AR1

affects_phosphorylation of

gene/protein

AKT1

in liver, in epididymal white adipose tissue; after insulin challange, after high-fat diet
Drugbank entries Show/Hide entries for AKT1
Comment Macrophage infiltration in the adipose tissue was assessed by quantifying the levels of two macrophage markers (F4/80 and CD68). Staining of adipose tissue sections with an anti-F4/80 antibody revealed a significant decrease in macrophage infiltration in WAT from C3aR-/- mice on HFD.
Formal Description
Interaction-ID: 8341

gene/protein

C3AR1

affects_quantity of

tissue/cell line

macrophage

in white adipose tissue; after high-fat diet
Comment MCP-1 and IL-6 are adipokines believed to initiate macrophage infiltration in the WAT and involved in systemic insulin resistance. Indeed, a significant increase in MCP-1 mRNA levels was seen in wild-type mice on HFD compared with ND (fourfold). MCP-1 expression in C3aR-/- mice on HFD was 1.7-fold lower than wild-type controls. A definitive trend toward decreased IL-6 expression was seen in both the C3aR-/- and C3aR-/- mice on HFD compared with wild type.
Formal Description
Interaction-ID: 8342

environment

high-fat diet

increases_expression of

gene/protein

CCL2

Drugbank entries Show/Hide entries for CCL2
Comment MCP-1 and IL-6 are adipokines believed to initiate macrophage infiltration in the WAT and involved in systemic insulin resistance. Indeed, a significant increase in MCP-1 mRNA levels was seen in wild-type mice on HFD compared with ND (fourfold). MCP-1 expression in C3aR-/- mice on HFD was 1.7-fold lower than wild-type controls. A definitive trend toward decreased IL-6 expression was seen in both the C3aR-/- and C3aR-/- mice on HFD compared with wild type.
Formal Description
Interaction-ID: 8371

gene/protein

C3AR1

affects_expression of

gene/protein

CCL2

Drugbank entries Show/Hide entries for CCL2
Comment MCP-1 and IL-6 are adipokines believed to initiate macrophage infiltration in the WAT and involved in systemic insulin resistance. Indeed, a significant increase in MCP-1 mRNA levels was seen in wild-type mice on HFD compared with ND (fourfold). MCP-1 expression in C3aR-/- mice on HFD was 1.7-fold lower than wild-type controls. A definitive trend toward decreased IL-6 expression was seen in both the C3aR-/- and C3aR-/- mice on HFD compared with wild type.
Formal Description
Interaction-ID: 8372

gene/protein

C3AR1

affects_expression of

gene/protein

IL6

Drugbank entries Show/Hide entries for IL6
Comment Arginases are overexpressed in M2 macrophages and believed to be involved in adipose tissue repair. Adipose tissue from C3aR-/- mice on ND showed a dramatic increase in Arg2. Arg2 levels are also increased in the knockout mice on HFD to a lesser extent than on ND. No change in other M2-specific genes (Arg1, Mrc2, Mgl1, Mgl2, and Ym1) was detected in eWAT.
Formal Description
Interaction-ID: 8373

gene/protein

C3AR1

affects_expression of

gene/protein

ARG2

in epididymal white adipose tissue
Drugbank entries Show/Hide entries for ARG2
Comment Arginases are overexpressed in M2 macrophages and believed to be involved in adipose tissue repair. Adipose tissue from C3aR-/- mice on ND showed a dramatic increase in Arg2. Arg2 levels are also increased in the knockout mice on HFD to a lesser extent than on ND. No change in other M2-specific genes (Arg1, Mrc2, Mgl1, Mgl2, and Ym1) was detected in eWAT.
Formal Description
Interaction-ID: 8374

gene/protein

C3AR1

NOT affects_expression of

gene/protein

ARG1

in epididymal white adipose tissue
Drugbank entries Show/Hide entries for ARG1
Comment Arginases are overexpressed in M2 macrophages and believed to be involved in adipose tissue repair. Adipose tissue from C3aR-/- mice on ND showed a dramatic increase in Arg2. Arg2 levels are also increased in the knockout mice on HFD to a lesser extent than on ND. No change in other M2-specific genes (Arg1, Mrc2, Mgl1, Mgl2, and Ym1) was detected in eWAT.
Formal Description
Interaction-ID: 8375

gene/protein

C3AR1

NOT affects_expression of

gene/protein

MRC2

in epididymal white adipose tissue
Comment Arginases are overexpressed in M2 macrophages and believed to be involved in adipose tissue repair. Adipose tissue from C3aR-/- mice on ND showed a dramatic increase in Arg2. Arg2 levels are also increased in the knockout mice on HFD to a lesser extent than on ND. No change in other M2-specific genes (Arg1, Mrc2, Mgl1, Mgl2, and Ym1) was detected in eWAT.
Formal Description
Interaction-ID: 8376

gene/protein

C3AR1

NOT affects_expression of

gene/protein

MGL1

in epididymal white adipose tissue
Comment Arginases are overexpressed in M2 macrophages and believed to be involved in adipose tissue repair. Adipose tissue from C3aR-/- mice on ND showed a dramatic increase in Arg2. Arg2 levels are also increased in the knockout mice on HFD to a lesser extent than on ND. No change in other M2-specific genes (Arg1, Mrc2, Mgl1, Mgl2, and Ym1) was detected in eWAT.
Formal Description
Interaction-ID: 8377

gene/protein

C3AR1

NOT affects_expression of

gene/protein

MGL2

in epididymal white adipose tissue
Comment Arginases are overexpressed in M2 macrophages and believed to be involved in adipose tissue repair. Adipose tissue from C3aR-/- mice on ND showed a dramatic increase in Arg2. Arg2 levels are also increased in the knockout mice on HFD to a lesser extent than on ND. No change in other M2-specific genes (Arg1, Mrc2, Mgl1, Mgl2, and Ym1) was detected in eWAT.
Formal Description
Interaction-ID: 8378

gene/protein

C3AR1

NOT affects_expression of

gene/protein

CHI3L1

in epididymal white adipose tissue
Drugbank entries Show/Hide entries for CHI3L1
Comment The expression of several adipogenesis genes was investigated: peroxisome proliferator-activated receptor gamma, CD36, LPL, DGAT1, and aP2, as well as fatty oxidation genes: uncoupling protein-2, PDK2, PDK4, and Acadl in subcutaneous and abdominal WAT of wild-type and C3aR-/- mice on ND and HFD. No significant difference was observed in the expression of these genes in both fat depots.
Formal Description
Interaction-ID: 8382

gene/protein

C3AR1

NOT affects_expression of

gene/protein

PPARG

in epididymal white adipose tissue, in subcutaneous adipose tissue
Drugbank entries Show/Hide entries for PPARG
Comment The expression of several adipogenesis genes was investigated: peroxisome proliferator-activated receptor gamma, CD36, LPL, DGAT1, and aP2, as well as fatty oxidation genes: uncoupling protein-2, PDK2, PDK4, and Acadl in subcutaneous and abdominal WAT of wild-type and C3aR-/- mice on ND and HFD. No significant difference was observed in the expression of these genes in both fat depots.
Formal Description
Interaction-ID: 8386

gene/protein

C3AR1

NOT affects_expression of

gene/protein

CD36

in epididymal white adipose tissue, in subcutaneous adipose tissue
Comment The expression of several adipogenesis genes was investigated: peroxisome proliferator-activated receptor gamma, CD36, LPL, DGAT1, and aP2, as well as fatty oxidation genes: uncoupling protein-2, PDK2, PDK4, and Acadl in subcutaneous and abdominal WAT of wild-type and C3aR-/- mice on ND and HFD. No significant difference was observed in the expression of these genes in both fat depots.
Formal Description
Interaction-ID: 8390

gene/protein

C3AR1

NOT affects_expression of

gene/protein

LPL

in epididymal white adipose tissue, in subcutaneous adipose tissue
Drugbank entries Show/Hide entries for LPL
Comment The expression of several adipogenesis genes was investigated: peroxisome proliferator-activated receptor gamma, CD36, LPL, DGAT1, and aP2, as well as fatty oxidation genes: uncoupling protein-2, PDK2, PDK4, and Acadl in subcutaneous and abdominal WAT of wild-type and C3aR-/- mice on ND and HFD. No significant difference was observed in the expression of these genes in both fat depots.
Formal Description
Interaction-ID: 8395

gene/protein

C3AR1

NOT affects_expression of

gene/protein

DGAT1

in epididymal white adipose tissue, in subcutaneous adipose tissue
Comment The expression of several adipogenesis genes was investigated: peroxisome proliferator-activated receptor gamma, CD36, LPL, DGAT1, and aP2, as well as fatty oxidation genes: uncoupling protein-2, PDK2, PDK4, and Acadl in subcutaneous and abdominal WAT of wild-type and C3aR-/- mice on ND and HFD. No significant difference was observed in the expression of these genes in both fat depots.
Formal Description
Interaction-ID: 8397

gene/protein

C3AR1

NOT affects_expression of

gene/protein

TFAP2A

in epididymal white adipose tissue, in subcutaneous adipose tissue
Comment The expression of several adipogenesis genes was investigated: peroxisome proliferator-activated receptor gamma, CD36, LPL, DGAT1, and aP2, as well as fatty oxidation genes: uncoupling protein-2, PDK2, PDK4, and Acadl in subcutaneous and abdominal WAT of wild-type and C3aR-/- mice on ND and HFD. No significant difference was observed in the expression of these genes in both fat depots.
Formal Description
Interaction-ID: 8398

gene/protein

C3AR1

NOT affects_expression of

gene/protein

UCP2

in epididymal white adipose tissue, in subcutaneous adipose tissue
Comment The expression of several adipogenesis genes was investigated: peroxisome proliferator-activated receptor gamma, CD36, LPL, DGAT1, and aP2, as well as fatty oxidation genes: uncoupling protein-2, PDK2, PDK4, and Acadl in subcutaneous and abdominal WAT of wild-type and C3aR-/- mice on ND and HFD. No significant difference was observed in the expression of these genes in both fat depots.
Formal Description
Interaction-ID: 8399

gene/protein

C3AR1

NOT affects_expression of

gene/protein

PDK2

in epididymal white adipose tissue, in subcutaneous adipose tissue
Drugbank entries Show/Hide entries for PDK2
Comment The expression of several adipogenesis genes was investigated: peroxisome proliferator-activated receptor gamma, CD36, LPL, DGAT1, and aP2, as well as fatty oxidation genes: uncoupling protein-2, PDK2, PDK4, and Acadl in subcutaneous and abdominal WAT of wild-type and C3aR-/- mice on ND and HFD. No significant difference was observed in the expression of these genes in both fat depots.
Formal Description
Interaction-ID: 8400

gene/protein

C3AR1

NOT affects_expression of

gene/protein

PDK4

in epididymal white adipose tissue, in subcutaneous adipose tissue
Drugbank entries Show/Hide entries for PDK4
Comment The expression of several adipogenesis genes was investigated: peroxisome proliferator-activated receptor gamma, CD36, LPL, DGAT1, and aP2, as well as fatty oxidation genes: uncoupling protein-2, PDK2, PDK4, and Acadl in subcutaneous and abdominal WAT of wild-type and C3aR-/- mice on ND and HFD. No significant difference was observed in the expression of these genes in both fat depots.
Formal Description
Interaction-ID: 8402

gene/protein

C3AR1

NOT affects_expression of

gene/protein

ACADL

in epididymal white adipose tissue, in subcutaneous adipose tissue
Comment No significant difference in the expression of thermogenesis-related genes, uncoupling protein-1, and PPAR-gamma coactivator-1alpha in BAT was observed in wild-type and C3aR-/- mice.
Formal Description
Interaction-ID: 8403

gene/protein

C3AR1

NOT affects_expression of

gene/protein

UCP1

in brown adipose tissue
Comment No significant difference in the expression of thermogenesis-related genes, uncoupling protein-1, and PPAR-gamma coactivator-1alpha in BAT was observed in wild-type and C3aR-/- mice.
Formal Description
Interaction-ID: 8404

gene/protein

C3AR1

NOT affects_expression of

gene/protein

PPARGC1A

in brown adipose tissue
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8405

environment

high-fat diet

increases_quantity of

gene/protein

CCL2

Drugbank entries Show/Hide entries for CCL2
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8406

gene/protein

C3AR1

NOT affects_quantity of

gene/protein

CCL2

after high-fat diet
Drugbank entries Show/Hide entries for CCL2
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8407

environment

high-fat diet

increases_quantity of

gene/protein

IL6

Drugbank entries Show/Hide entries for IL6
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8408

gene/protein

C3AR1

NOT affects_quantity of

gene/protein

IL6

after high-fat diet
Drugbank entries Show/Hide entries for IL6
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8409

environment

high-fat diet

increases_quantity of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8410

gene/protein

C3AR1

NOT affects_quantity of

gene/protein

TNF

after high-fat diet
Drugbank entries Show/Hide entries for TNF
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8411

environment

high-fat diet

increases_quantity of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8413

gene/protein

C3AR1

NOT affects_quantity of

gene/protein

IL1B

after high-fat diet
Drugbank entries Show/Hide entries for IL1B
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8415

environment

high-fat diet

increases_quantity of

gene/protein

CCL5

Drugbank entries Show/Hide entries for CCL5
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8416

gene/protein

C3AR1

NOT affects_quantity of

gene/protein

CCL5

after high-fat diet
Drugbank entries Show/Hide entries for CCL5
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8417

environment

high-fat diet

increases_quantity of

gene/protein

IL2

Drugbank entries Show/Hide entries for IL2
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8418

gene/protein

C3AR1

NOT affects_quantity of

gene/protein

IL2

after high-fat diet
Drugbank entries Show/Hide entries for IL2
Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8419

environment

high-fat diet

increases_quantity of

gene/protein

IL10

Comment A significant increase in proinflammatory cytokines (MCP-1, IL-6, TNF-alpha, IL-1beta, RANTES, IL-2, IL-10) was seen in wild-type mice after 8 weeks of HFD compared with ND. No such increase in the proinflammatory mediators was seen in the C3aR-/- mice on HFD; in wild-type and C3aR-/- mice on ND the leves were comparable.
Formal Description
Interaction-ID: 8420

gene/protein

C3AR1

NOT affects_quantity of

gene/protein

IL10

after high-fat diet
Comment C3aR-/- M1 bone marrow-derived macrophages possessed a considerably decreased expression of Nos1, Nos2, and MARCO (M1 markers) compared with wild-type mice.
Formal Description
Interaction-ID: 8421

gene/protein

C3AR1

affects_expression of

gene/protein

NOS1

in M1 bone marrow-derived macrophages
Drugbank entries Show/Hide entries for NOS1
Comment C3aR-/- M1 bone marrow-derived macrophages possessed a considerably decreased expression of Nos1, Nos2, and MARCO (M1 markers) compared with wild-type mice.
Formal Description
Interaction-ID: 8422

gene/protein

C3AR1

affects_expression of

gene/protein

NOS2

in M1 bone marrow-derived macrophages
Drugbank entries Show/Hide entries for NOS2
Comment C3aR-/- M1 bone marrow-derived macrophages possessed a considerably decreased expression of Nos1, Nos2, and MARCO (M1 markers) compared with wild-type mice.
Formal Description
Interaction-ID: 8423

gene/protein

C3AR1

affects_expression of

gene/protein

MARCO

in M1 bone marrow-derived macrophages
Comment C3aR deletion decreases proinflammatory cytokines and M1-specific gene expression in macrophages.
Formal Description
Interaction-ID: 8424

gene/protein

C3AR1

affects_quantity of

gene/protein

Proinflammatory cytokine

in macrophages