General Information:

Id: 122 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Grimes CA and Jope RS(2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog. Neurobiol. 65: 391-426 [PMID: 11527574]

Interaction Information:

Comment Presenilin 1 can facilitate the co-localization of GSK3B and tau.
Formal Description
Interaction-ID: 907

gene/protein

PSEN1

increases_activity of

of GSK3B and MAPT/TAU
Comment Presenilin 1 binds to GSK3B. Mutant forms of presenilin 1 can modify the activity and function of GSK3B.
Formal Description
Interaction-ID: 908

gene/protein

PSEN1

interacts (colocalizes) with

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Presenilin 1 is capable of modulating its activity by regulating Akt.
Formal Description
Interaction-ID: 909

gene/protein

PSEN1

affects_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1