General Information:

Id: 122 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Grimes CA and Jope RS(2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog. Neurobiol. 65: 391-426 [PMID: 11527574]

Interaction Information:

Comment Abeta-activated GSK3B phosphorylated and inactivated pyruvate dehydrogenase, resulting in reduced synthesis of acetylcholine due to depletion of its precursor acetyl coenzyme A.
Formal Description
Interaction-ID: 865

gene/protein

GSK3B

increases_phosphorylation of

complex/PPI

Pyruvate dehydrogenase complex

Drugbank entries Show/Hide entries for GSK3B