General Information:

Id: 122 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Grimes CA and Jope RS(2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog. Neurobiol. 65: 391-426 [PMID: 11527574]

Interaction Information:

Comment GSK3B increases the cellular maturation of the amyloid precursor protein which may alter the production of the Alzheimer's disease-associated amyloid-beta (Abeta) peptide.
Formal Description
Interaction-ID: 487

gene/protein

GSK3B

affects_quantity of

gene/protein

Amyloid beta peptide

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Comment Abeta-induced neurotoxicity was reduced by antisense GSK3B oligonucleotides and by the GSK3B inhibitor lithium.
Formal Description
Interaction-ID: 864

drug/chemical compound

Lithium

affects_activity of

gene/protein

Amyloid beta peptide

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Comment GSK3beta is activated by amyloid beta peptide and phosphorylates APP.
Formal Description
Interaction-ID: 14051

gene/protein

Amyloid beta peptide

increases_activity of

gene/protein

GSK3B

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