General Information:

Id: 122 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Grimes CA and Jope RS(2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog. Neurobiol. 65: 391-426 [PMID: 11527574]

Interaction Information:

Comment In the absence of Wnt, GSK3B is complexed with Axin and APC and phosphorylates beta-catenin, targeting it for degradation.
Formal Description
Interaction-ID: 754

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

CTNNB1

in the absence of Wnt and if GSK3B is complexed with Axin and APC;
Drugbank entries Show/Hide entries for GSK3B or CTNNB1