General Information:

Id: 122 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Grimes CA and Jope RS(2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog. Neurobiol. 65: 391-426 [PMID: 11527574]

Interaction Information:

Comment Inhibition of GSK3B results in increased beta-catenin levels, its translocation to the nucleus, and facilitation of Tcf/Lef-mediated transcription.
Formal Description
Interaction-ID: 455

gene/protein

GSK3B

decreases_quantity of

gene/protein

CTNNB1

by phosphorylating beta-catenin, targeting it for degradation;
Drugbank entries Show/Hide entries for GSK3B or CTNNB1