General Information:

Id: 122
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Grimes CA and Jope RS(2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog. Neurobiol. 65: 391-426 [PMID: 11527574]

Interaction Information:

Comment GSK3beta is activated by amyloid beta peptide and phosphorylates APP.
Formal Description
Interaction-ID: 419

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

APP

Drugbank entries Show/Hide entries for GSK3B or APP
Comment GSK3B phosphorylates APC.
Formal Description
Interaction-ID: 420

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

APC

Drugbank entries Show/Hide entries for GSK3B
Comment IRS1 is phosphorylated by GSK3B.
Formal Description
Interaction-ID: 445

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

IRS1

Drugbank entries Show/Hide entries for GSK3B or IRS1
Comment Myelin basic protein (MBP) is phosphorylated by GSK3B.
Formal Description
Interaction-ID: 446

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

MBP

Drugbank entries Show/Hide entries for GSK3B
Comment MAP1B and MAP2 also are phosphorylated by GSK3beta.
Formal Description
Interaction-ID: 447

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

MAP1B

Drugbank entries Show/Hide entries for GSK3B
Comment MAP1B and MAP2 also are phosphorylated by GSK3beta.
Formal Description
Interaction-ID: 450

gene/protein

GSK3B

affects_phosphorylation of

gene/protein

MAP2

Drugbank entries Show/Hide entries for GSK3B or MAP2
Comment Ninein (NN) is phosphorylated by GSK3B.
Formal Description
Interaction-ID: 452

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

NIN

Drugbank entries Show/Hide entries for GSK3B
Comment GSK3beta phosphorylates TAU / MAPT, which might contribute to neurofibrillary tangle formation.
Formal Description
Interaction-ID: 453

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

MAPT

Drugbank entries Show/Hide entries for GSK3B
Comment GSK3beta phosphorylated c-Jun in vitro at three sites, including Thr-239, Ser-243, and Ser-249, and decreased its DNA binding activity.
Formal Description
Interaction-ID: 454

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

JUN

Drugbank entries Show/Hide entries for GSK3B or JUN
Comment Inhibition of GSK3B results in increased beta-catenin levels, its translocation to the nucleus, and facilitation of Tcf/Lef-mediated transcription.
Formal Description
Interaction-ID: 455

gene/protein

GSK3B

decreases_quantity of

gene/protein

CTNNB1

by phosphorylating beta-catenin, targeting it for degradation;
Drugbank entries Show/Hide entries for GSK3B or CTNNB1
Comment CEBPA is phosphorylated by GSK3b.
Formal Description
Interaction-ID: 456

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

CEBPA

Drugbank entries Show/Hide entries for GSK3B
Comment CREB is phosphorylated by GSK3b.
Formal Description
Interaction-ID: 457

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

CREB1

Drugbank entries Show/Hide entries for GSK3B or CREB1
Comment GSK3beta has an inhibitory effect on the activation of HSF-1.
Formal Description
Interaction-ID: 458

gene/protein

GSK3B

decreases_activity of

gene/protein

HSF1

Drugbank entries Show/Hide entries for GSK3B
Comment GSK3beta can phosphorylate serine residues 38, 42, and 62, and threonine residue 58 within the transactivation domain of Myc, sites considered important for regulation of Myc transcriptional activity in vivo.
Formal Description
Interaction-ID: 459

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

MYC

the serine residues 38, 42, and 62, and threonine residue 58 within the transactivation domain of Myc.
Drugbank entries Show/Hide entries for GSK3B
Comment GSK3B is regulated by Wnt signaling. In the absence of Wnt, GSK3B is complexed with Axin and APC and phosphorylates beta-catenin, targeting it for degradation.
Formal Description
Interaction-ID: 463

affects_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Phosphorylation of Axin by GSK3B stabilizes Axin.
Formal Description
Interaction-ID: 464

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

AXIN1

Drugbank entries Show/Hide entries for GSK3B or AXIN1
Comment GSK3B is complexed with Axin and APC and phosphorylates beta-catenin, targeting it for degradation.
Formal Description
Interaction-ID: 465

gene/protein

GSK3B

interacts (colocalizes) with

Drugbank entries Show/Hide entries for GSK3B
Comment GSK3B inhibited by phosphorylation at Ser9 could be reactivated with protein phosphatase 2A.
Formal Description
Interaction-ID: 479

complex/PPI

PP2A complex

decreases_phosphorylation of

protein modification

GSK3B-phosSer9

Comment GSK3B inhibited by phosphorylation at Ser9 could be reactivated with protein phosphatase 2A.
Formal Description
Interaction-ID: 480

complex/PPI

PP2A complex

increases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment GSK3B phosphorylates Thr-743 of the amyloid precursor protein.
Formal Description
Interaction-ID: 481

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

APP

at Thr743
Drugbank entries Show/Hide entries for GSK3B or APP
Comment GSK3B increases the cellular maturation of the amyloid precursor protein which may alter the production of the Alzheimer's disease-associated amyloid-beta (Abeta) peptide.
Formal Description
Interaction-ID: 482

gene/protein

GSK3B

increases_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for GSK3B or APP
Comment GSK3B increases the cellular maturation of the amyloid precursor protein which may alter the production of the Alzheimer's disease-associated amyloid-beta (Abeta) peptide.
Formal Description
Interaction-ID: 487

gene/protein

GSK3B

affects_quantity of

gene/protein

Amyloid beta peptide

Drugbank entries Show/Hide entries for GSK3B
Comment Ser-9 of GSK3beta is phosphorylated (and thus inhibited) by protein kinase A.
Formal Description
Interaction-ID: 491

gene/protein

PRKAR2A

increases_phosphorylation of

gene/protein

GSK3B

at Ser9
Drugbank entries Show/Hide entries for GSK3B
Comment ACLY is phosphorylated by GSK3beta.
Formal Description
Interaction-ID: 492

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

ACLY

Drugbank entries Show/Hide entries for GSK3B
Comment GSK3beta phosphorylates PPP1R2.
Formal Description
Interaction-ID: 493

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

PPP1R2

Drugbank entries Show/Hide entries for GSK3B
Comment Lithium, the primary therapeutic agent for bipolar mood disorder, is a selective inhibitor of GSK3beta.
Formal Description
Interaction-ID: 494

drug/chemical compound

Lithium

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for Lithium or GSK3B
Comment GSK3B phosphorylates eIF2B at Ser-540 and inhibits its activity.
Formal Description
Interaction-ID: 495

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

EIF2B5

at Ser540, hereby inhibiting EIF2B5.
Drugbank entries Show/Hide entries for GSK3B
Comment GSK3B phosphorylates eIF2B at Ser-540 and inhibits its activity.
Formal Description
Interaction-ID: 496

gene/protein

GSK3B

decreases_activity of

gene/protein

EIF2B5

by phosphorylation at Ser540.
Drugbank entries Show/Hide entries for GSK3B
Comment Lithium activates the Wnt signaling pathway.
Formal Description
Interaction-ID: 570

drug/chemical compound

Lithium

increases_activity of

Drugbank entries Show/Hide entries for Lithium
Comment Lithium treatment resulted in decreased levels of Axin.
Formal Description
Interaction-ID: 583

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

AXIN1

Drugbank entries Show/Hide entries for Lithium or AXIN1
Comment Lithium reduced tau phosphorylation.
Formal Description
Interaction-ID: 588

drug/chemical compound

Lithium

decreases_quantity of

protein modification

MAPT-phos

Drugbank entries Show/Hide entries for Lithium
Comment Maleimide and indirubin caused selective and potent inhibition of GSK3beta.
Formal Description
Interaction-ID: 593

drug/chemical compound

Maleimide

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Maleimide and indirubin caused selective and potent inhibition of GSK3beta.
Formal Description
Interaction-ID: 594

drug/chemical compound

Indirubin

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Increased nuclear GSK3beta was induced by heat shock.
Formal Description
Interaction-ID: 618

increases_quantity of

gene/protein

GSK3B

in nucleus
Drugbank entries Show/Hide entries for GSK3B
Comment Cell stressors can modulate the activity of GSK3beta, as both heat shock and oxidative stress can cause inhibition of GSK3beta.
Formal Description
Interaction-ID: 620

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Protein kinase C alpha phosphorylates and inactivates GSK3B.
Formal Description
Interaction-ID: 646

gene/protein

PRKCA

increases_phosphorylation of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for PRKCA or GSK3B
Comment Protein kinase C alpha phosphorylates and inactivates GSK3B.
Formal Description
Interaction-ID: 647

gene/protein

PRKCA

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for PRKCA or GSK3B
Comment Protein kinase C beta phosphorylates and inactivates GSK3B.
Formal Description
Interaction-ID: 648

gene/protein

PRKCB

increases_phosphorylation of

gene/protein

GSK3B

hereby inactivating GSK3B.
Drugbank entries Show/Hide entries for PRKCB or GSK3B
Comment Protein kinase C beta phosphorylates and inactivates GSK3B.
Formal Description
Interaction-ID: 649

gene/protein

PRKCB

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for PRKCB or GSK3B
Comment Protein kinase C gamma phosphorylates and inactivates GSK3B.
Formal Description
Interaction-ID: 650

gene/protein

PRKCG

increases_phosphorylation of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Protein kinase C gamma phosphorylates and inactivates GSK3B.
Formal Description
Interaction-ID: 651

gene/protein

PRKCG

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B