Su X et al.(2008) Synuclein activates microglia in a model of Parkinsons disease Neurobiol. Aging 29: 1690-1701
[PMID: 17537546]
Interaction Information:
Comment
SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation.