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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	1,218 (click here to show other Interactions for entry)
Diseases:	Parkinson disease
Organism:	Mus musculus
Organism Model:	SYN-WT+/+, transgenic mouse model overexpressing human wild-type SYN under control of the 9-kb rat tyrosine hydroxylase promoter
Tissue/Cell line:	BTO:0000078 microglia
Publication type:	article
Reference:	Su X et al.(2008) Synuclein activates microglia in a model of Parkinsons disease Neurobiol. Aging 29: 1690-1701 [PMID: 17537546]

Interaction Information:

Comment	SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation.
Formal Description Interaction-ID: 8192	gene/protein SNCA increases_expression of gene/protein IL6 via microglial cell activation
Drugbank entries	Show/Hide entries for IL6
Drugbank DB01404	Ginseng antagonist IL6
Drugbank DB01404	Ginseng antagonist IL6

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