General Information:

Id: 1,218 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
SYN-WT+/+, transgenic mouse model overexpressing human wild-type SYN under control of the 9-kb rat tyrosine hydroxylase promoter
BTO:0000078 microglia
article
Reference: Su X et al.(2008) Synuclein activates microglia in a model of Parkinsons disease Neurobiol. Aging 29: 1690-1701 [PMID: 17537546]

Interaction Information:

Comment SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation.
Formal Description
Interaction-ID: 8192

gene/protein

SNCA

increases_expression of

gene/protein

IL6

via microglial cell activation
Drugbank entries Show/Hide entries for IL6