General Information:

Id: 1,218 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
SYN-WT+/+, transgenic mouse model overexpressing human wild-type SYN under control of the 9-kb rat tyrosine hydroxylase promoter
BTO:0000078 microglia
article
Reference: Su X et al.(2008) Synuclein activates microglia in a model of Parkinsons disease Neurobiol. Aging 29: 1690-1701 [PMID: 17537546]

Interaction Information:

Comment Expression of TNFalpha increases in SYN-WT+/+ compared to age-match NTG mice. The up-regulation of this proinflammatory molecule supports a role for inflammation and microglial activation in this model of SYN overexpression.
Formal Description
Interaction-ID: 8184

gene/protein

TNF

increases_activity of

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