CIDeRGeneral Information:
| Id: | 1,217 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| female | |
| article | |
| Reference: | Riant E et al.(2009) Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice Endocrinology 150: 2109-2117 [PMID: 19164473] |
Interaction Information:
| Comment | Although E2 treatment did not influence the level of cytokines after 1 month of high-fat feeding, it significantly increased the plasma levels of IL-6 (16.6-fold), TNF-alpha (16.5-fold), and IL-1beta (2.8-fold) in mice fed with this diet for 3 months. |
|
Formal Description Interaction-ID: 8201 |
|
| Drugbank entries | Show/Hide entries for Estradiol or IL6 |
| Comment | During the short-term high-fat feeding period, E2 treatment significantly increased the level of IL-6, TNF-alpha, and PAI-1 mRNAs in both the liver and visceral adipose tissue, compared with results obtained in placebo-treated ovariectomized mice. |
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Formal Description Interaction-ID: 8204 |
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| Drugbank entries | Show/Hide entries for Estradiol or IL6 |