General Information:

Id: 1,217
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
female
article
Reference: Riant E et al.(2009) Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice Endocrinology 150: 2109-2117 [PMID: 19164473]

Interaction Information:

Comment Estradiol administration protects from the glucose intolerance induced by high fat feeding.
Formal Description
Interaction-ID: 8170

drug/chemical compound

Estradiol

decreases_activity of

after high-fat diet
Drugbank entries Show/Hide entries for Estradiol
Comment E2 administration prevents insulin resistance in HFD-fed mice.
Formal Description
Interaction-ID: 8174

drug/chemical compound

Estradiol

decreases_activity of

disease

Insulin resistance

after high-fat diet
Drugbank entries Show/Hide entries for Estradiol
Comment Circulating adiponectin levels were significantly reduced in E2-treated mice exposed to the HFD for either 1 or 3 months.
Formal Description
Interaction-ID: 8176

drug/chemical compound

Estradiol

decreases_quantity of

gene/protein

ADIPOQ

in blood; after high-fat diet
Drugbank entries Show/Hide entries for Estradiol
Comment E2 administration improves insulin signaling in muscles.
Formal Description
Interaction-ID: 8177

drug/chemical compound

Estradiol

increases_activity of

in muscle
Drugbank entries Show/Hide entries for Estradiol
Comment E2 administration enhanced IRS-1 protein concentration (1.7-fold).
Formal Description
Interaction-ID: 8178

drug/chemical compound

Estradiol

increases_quantity of

gene/protein

IRS1

Drugbank entries Show/Hide entries for Estradiol or IRS1
Comment The concentrations of the phosphorylated form of Akt at the Ser-473 (1.6-fold) and the Thr-308 (2.7-fold) sites were significantly increased in muscles from E2-treated mice, demonstrating that E2 preserves insulin signaling from the deleterious effect of high fat feeding.
Formal Description
Interaction-ID: 8179

drug/chemical compound

Estradiol

increases_phosphorylation of

gene/protein

AKT1

in muscle; after high-fat diet, at Ser473 and Thr308 of AKT1
Drugbank entries Show/Hide entries for Estradiol or AKT1
Comment E2 treatment increased the concentration of AMPK phosphorylation form, only in the presence of insulin, in skeletal muscles.
Formal Description
Interaction-ID: 8200

drug/chemical compound

Estradiol

increases_phosphorylation of

complex/PPI

AMPK

in skeletal muscle; in the presence of insulin
Drugbank entries Show/Hide entries for Estradiol
Comment Although E2 treatment did not influence the level of cytokines after 1 month of high-fat feeding, it significantly increased the plasma levels of IL-6 (16.6-fold), TNF-alpha (16.5-fold), and IL-1beta (2.8-fold) in mice fed with this diet for 3 months.
Formal Description
Interaction-ID: 8201

drug/chemical compound

Estradiol

increases_quantity of

gene/protein

IL6

in blood; after 3 months of high-fat diet
Drugbank entries Show/Hide entries for Estradiol or IL6
Comment Although E2 treatment did not influence the level of cytokines after 1 month of high-fat feeding, it significantly increased the plasma levels of IL-6 (16.6-fold), TNF-alpha (16.5-fold), and IL-1beta (2.8-fold) in mice fed with this diet for 3 months.
Formal Description
Interaction-ID: 8202

drug/chemical compound

Estradiol

increases_quantity of

gene/protein

TNF

in blood; after 3 months of high-fat diet
Drugbank entries Show/Hide entries for Estradiol or TNF
Comment Although E2 treatment did not influence the level of cytokines after 1 month of high-fat feeding, it significantly increased the plasma levels of IL-6 (16.6-fold), TNF-alpha (16.5-fold), and IL-1beta (2.8-fold) in mice fed with this diet for 3 months.
Formal Description
Interaction-ID: 8203

drug/chemical compound

Estradiol

increases_quantity of

gene/protein

IL1B

in blood; after 3 months of high-fat diet
Drugbank entries Show/Hide entries for Estradiol or IL1B
Comment During the short-term high-fat feeding period, E2 treatment significantly increased the level of IL-6, TNF-alpha, and PAI-1 mRNAs in both the liver and visceral adipose tissue, compared with results obtained in placebo-treated ovariectomized mice.
Formal Description
Interaction-ID: 8204

drug/chemical compound

Estradiol

increases_expression of

gene/protein

IL6

in liver, in visceral adipose tissue; after 1 month of high-fat feeding
Drugbank entries Show/Hide entries for Estradiol or IL6
Comment During the short-term high-fat feeding period, E2 treatment significantly increased the level of IL-6, TNF-alpha, and PAI-1 mRNAs in both the liver and visceral adipose tissue, compared with results obtained in placebo-treated ovariectomized mice.
Formal Description
Interaction-ID: 8206

drug/chemical compound

Estradiol

increases_expression of

gene/protein

TNF

in liver, in visceral adipose tissue; after 1 month of high-fat feeding
Drugbank entries Show/Hide entries for Estradiol or TNF
Comment During the short-term high-fat feeding period, E2 treatment significantly increased the level of IL-6, TNF-alpha, and PAI-1 mRNAs in both the liver and visceral adipose tissue, compared with results obtained in placebo-treated ovariectomized mice.
Formal Description
Interaction-ID: 8207

drug/chemical compound

Estradiol

increases_expression of

gene/protein

SERPINE1

in liver, in visceral adipose tissue; after 1 month of high-fat feeding
Drugbank entries Show/Hide entries for Estradiol or SERPINE1
Comment E2 administration resulted in a significant elevation of F4/80 mRNA levels in subcutaneous (2.1-fold) and visceral (1.6-fold) adipose tissues, providing further evidence that E2 increases the density of macrophages in adipose tissues.
Formal Description
Interaction-ID: 8208

drug/chemical compound

Estradiol

increases_expression of

gene/protein

ADGRE1

in subcutaneous adipose tissue, in visceral adipose tissue
Drugbank entries Show/Hide entries for Estradiol
Comment E2 administration resulted in a significant elevation of F4/80 mRNA levels in subcutaneous (2.1-fold) and visceral (1.6-fold) adipose tissues, providing further evidence that E2 increases the density of macrophages in adipose tissues.
Formal Description
Interaction-ID: 8212

drug/chemical compound

Estradiol

increases_quantity of

tissue/cell line

macrophage

in subcutaneous adipose tissue, in visceral adipose tissue
Drugbank entries Show/Hide entries for Estradiol
Comment Although the proinflammatory effect of E2 was abolished in visceral adipose tissue from chimeric mice grafted with bone marrow cells from ERalpha-deficient mice, the beneficial effect of the hormone on glucose tolerance was not altered, suggesting that the metabolic and inflammatory effects of estrogens can be dissociated.
Formal Description
Interaction-ID: 8213

drug/chemical compound

Estradiol

increases_activity of

Drugbank entries Show/Hide entries for Estradiol
Comment Endogenous estrogens prevent insulin resistance and glucose intolerance in HFD-fed mice.
Formal Description
Interaction-ID: 8215

drug/chemical compound

endogenous estrogen

affects_activity of

disease

Insulin resistance

after high--fat diet