General Information:

Id: 1,213
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Lesniewski LA et al.(2007) Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance Nat. Med. 13: 455-462 [PMID: 17351624]

Interaction Information:

Comment Whole-body and organ weights did not differ between wild-type (Sorbs1+/+) and Sorbs1-/- mice fed on normal chow or high fat diet (HFD). After HFD, an 11-fold increase in liver triglyceride was seen in wild-type mice as compared with a twofold increase in Sorbs1-/- mice.
Formal Description
Interaction-ID: 8117

gene/protein

SORBS1

NOT affects_activity of

after normal chow diet, after high-fat diet
Comment No differences in plasma adiponectin were found between wild-type and Sorbs1-/- mice maintained on either normal chow or high fat diet.
Formal Description
Interaction-ID: 8118

gene/protein

SORBS1

NOT affects_quantity of

gene/protein

ADIPOQ

in blood
Comment Plasma leptin increased in both genotypes after high fat diet, but there were no differences between wild-type and Sorbs1-/- mice.
Formal Description
Interaction-ID: 8120

environment

high-fat diet

increases_quantity of

gene/protein

LEP

in blood
Comment Plasma leptin increased in both genotypes after high fat diet, but there were no differences between wild-type and Sorbs1-/- mice.
Formal Description
Interaction-ID: 8124

gene/protein

SORBS1

NOT affects_quantity of

gene/protein

LEP

in blood
Comment Wild-type mice developed the expected impaired glucose and insulin tolerance after high fat diet, but Sorbs1-/- mice were protected from high fat diet-induced defects in glucose and insulin homeostasis, Sorbs1 deletion protects against high fat diet-induced insulin resistance.
Formal Description
Interaction-ID: 8130

gene/protein

SORBS1

affects_activity of

disease

Insulin resistance

after high-fat diet
Comment Whereas circulating MCP-1 levels increased in wild-type mice after high fat diet, MCP-1 was unaltered in Sorbs1-/- mice.
Formal Description
Interaction-ID: 8133

environment

high-fat diet

increases_quantity of

gene/protein

CCL2

in blood
Drugbank entries Show/Hide entries for CCL2
Comment Whereas circulating MCP-1 levels increased in wild-type mice after high fat diet, MCP-1 was unaltered in Sorbs1-/- mice.
Formal Description
Interaction-ID: 8134

gene/protein

SORBS1

NOT affects_quantity of

gene/protein

CCL2

in blood; after high-fat diet
Drugbank entries Show/Hide entries for CCL2
Comment There was a marked (80%) reduction in the macrophage content of adipose tissue in Sorbs1-/- mice as compared with wild-type mice after either normal chow or high fat diet.
Formal Description
Interaction-ID: 8135

gene/protein

SORBS1

affects_quantity of

tissue/cell line

macrophage

in white adipose tissue
Comment There was also a significant reduction in the phosphorylated kinases IKK-beta and JNK in the white adipose tissue of Sorbs1-/- mice as compared with wild-type mice after high fat diet.
Formal Description
Interaction-ID: 8136

gene/protein

SORBS1

affects_phosphorylation of

gene/protein

IKBKB

in white adipose tissue; after high-fat diet
Drugbank entries Show/Hide entries for IKBKB
Comment There was also a significant reduction in the phosphorylated kinases IKK-beta and JNK in the white adipose tissue of Sorbs1-/- mice as compared with wild-type mice after high fat diet.
Formal Description
Interaction-ID: 8137

gene/protein

SORBS1

affects_phosphorylation of

gene/protein

MAPK8

in white adipose tissue; after high-fat diet
Drugbank entries Show/Hide entries for MAPK8
Comment Sorbs1 deletion reduces macrophage numbers and migration.
Formal Description
Interaction-ID: 8166

gene/protein

SORBS1

affects_activity of

Comment Using bone marrow transplantation to generate functional Sorbs1-null macrophages, it has been shown that the insulin-sensitive phenotype can be transferred to wild-type mice by transplantation of Sorbs1-null bone marrow. These studies show that macrophages are an important cell type in the induction of insulin resistance and that Cap has a modulatory role in this function.
Formal Description
Interaction-ID: 8167

tissue/cell line

macrophage

affects_activity of

disease

Insulin resistance

Comment Whole-body and organ weights did not differ between wild-type (Sorbs1+/+) and Sorbs1-/- mice fed on normal chow or high fat diet (HFD). After HFD, an 11-fold increase in liver triglyceride was seen in wild-type mice as compared with a twofold increase in Sorbs1-/- mice.
Formal Description
Interaction-ID: 13440

gene/protein

SORBS1

affects_quantity of

drug/chemical compound

Triacylglycerol

in liver; after high-fat diet
Comment Using bone marrow transplantation to generate functional Sorbs1-null macrophages, it has been shown that the insulin-sensitive phenotype can be transferred to wild-type mice by transplantation of Sorbs1-null bone marrow. These studies show that macrophages are an important cell type in the induction of insulin resistance and that Cap has a modulatory role in this function.
Formal Description
Interaction-ID: 13442

gene/protein

SORBS1

affects_activity of

disease

Insulin resistance