General Information:

Id: 1,211 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000099 astrocyte; BTO:0002126 U-373MG cell
article
Reference: Klegeris A et al.(2006) Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells FASEB J. 20: 2000-2008 [PMID: 17012252]

Interaction Information:

Comment Increase of the inflammation markers, ICAM-1 and IL-6, after expression of alpha-synuclein is associated with activation of major mitogen-activated protein kinase (MAPK) pathways.
Formal Description
Interaction-ID: 8150

process

stress-activated MAPK cascade

increases_quantity of

gene/protein

IL6

after addition of SNCA
Drugbank entries Show/Hide entries for IL6