General Information:

Id: 1,211 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000099 astrocyte; BTO:0002126 U-373MG cell
article
Reference: Klegeris A et al.(2006) Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells FASEB J. 20: 2000-2008 [PMID: 17012252]

Interaction Information:

Comment All WT and mutant forms (A30P, A53T, and E46K) of alpha-synuclein stimulate human astrocytes as well as human U373MG astrocytoma cells to up-regulate the inflammatory markers ICAM-1 and IL-6. The mutant forms were more potent then WT-alpha-synuclein.
Formal Description
Interaction-ID: 8127

gene/protein mutant

SNCA-p.E46K

increases_quantity of

gene/protein

IL6

in astrocytes; more efficiently than WT-alpha-synuclein
Drugbank entries Show/Hide entries for IL6