General Information:
Id: | 1,211 (click here to show other Interactions for entry) |
Diseases: |
Parkinson disease
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Homo sapiens | |
BTO:0000099 astrocyte; BTO:0002126 U-373MG cell | |
article | |
Reference: | Klegeris A et al.(2006) Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells FASEB J. 20: 2000-2008 [PMID: 17012252] |
Interaction Information:
Comment | All WT and mutant forms (A30P, A53T, and E46K) of alpha-synuclein stimulate human astrocytes as well as human U373MG astrocytoma cells to up-regulate the inflammatory markers ICAM-1 and IL-6. The mutant forms were more potent then WT-alpha-synuclein. |
Formal Description Interaction-ID: 8125 |
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Drugbank entries | Show/Hide entries for IL6 |