General Information:

Id: 1,211
Diseases: Parkinson disease
Homo sapiens
BTO:0000099 astrocyte; BTO:0002126 U-373MG cell
article
Reference: Klegeris A et al.(2006) Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells FASEB J. 20: 2000-2008 [PMID: 17012252]

Interaction Information:

Comment All WT and mutant forms (A30P, A53T, and E46K) of alpha-synuclein stimulate human astrocytes as well as human U373MG astrocytoma cells to up-regulate the inflammatory markers ICAM-1 and IL-6. The mutant forms were more potent then WT-alpha-synuclein.
Formal Description
Interaction-ID: 8109

gene/protein

SNCA

increases_quantity of

gene/protein

ICAM1

in astrocytes
Drugbank entries Show/Hide entries for ICAM1
Comment All WT and mutant forms (A30P, A53T, and E46K) of alpha-synuclein stimulate human astrocytes as well as human U373MG astrocytoma cells to up-regulate the inflammatory markers ICAM-1 and IL-6. The mutant forms were more potent then WT-alpha-synuclein.
Formal Description
Interaction-ID: 8121

gene/protein mutant

SNCA-p.A30P

increases_quantity of

gene/protein

ICAM1

in astrocytes; more efficiently than WT-alpha-synuclein
Drugbank entries Show/Hide entries for ICAM1
Comment All WT and mutant forms (A30P, A53T, and E46K) of alpha-synuclein stimulate human astrocytes as well as human U373MG astrocytoma cells to up-regulate the inflammatory markers ICAM-1 and IL-6. The mutant forms were more potent then WT-alpha-synuclein.
Formal Description
Interaction-ID: 8122

gene/protein mutant

SNCA-p.E46K

increases_quantity of

gene/protein

ICAM1

in astrocytes; more efficiently than WT-alpha-synuclein
Drugbank entries Show/Hide entries for ICAM1
Comment All WT and mutant forms (A30P, A53T, and E46K) of alpha-synuclein stimulate human astrocytes as well as human U373MG astrocytoma cells to up-regulate the inflammatory markers ICAM-1 and IL-6. The mutant forms were more potent then WT-alpha-synuclein.
Formal Description
Interaction-ID: 8123

gene/protein mutant

SNCA-p.A53T

increases_quantity of

gene/protein

ICAM1

in astrocytes; more efficiently than WT-alpha-synuclein
Drugbank entries Show/Hide entries for ICAM1
Comment All WT and mutant forms (A30P, A53T, and E46K) of alpha-synuclein stimulate human astrocytes as well as human U373MG astrocytoma cells to up-regulate the inflammatory markers ICAM-1 and IL-6. The mutant forms were more potent then WT-alpha-synuclein.
Formal Description
Interaction-ID: 8125

gene/protein

SNCA

increases_quantity of

gene/protein

IL6

in astrocytes
Drugbank entries Show/Hide entries for IL6
Comment All WT and mutant forms (A30P, A53T, and E46K) of alpha-synuclein stimulate human astrocytes as well as human U373MG astrocytoma cells to up-regulate the inflammatory markers ICAM-1 and IL-6. The mutant forms were more potent then WT-alpha-synuclein.
Formal Description
Interaction-ID: 8126

gene/protein mutant

SNCA-p.A30P

increases_quantity of

gene/protein

IL6

in astrocytes; more efficiently than WT-alpha-synuclein
Drugbank entries Show/Hide entries for IL6
Comment All WT and mutant forms (A30P, A53T, and E46K) of alpha-synuclein stimulate human astrocytes as well as human U373MG astrocytoma cells to up-regulate the inflammatory markers ICAM-1 and IL-6. The mutant forms were more potent then WT-alpha-synuclein.
Formal Description
Interaction-ID: 8127

gene/protein mutant

SNCA-p.E46K

increases_quantity of

gene/protein

IL6

in astrocytes; more efficiently than WT-alpha-synuclein
Drugbank entries Show/Hide entries for IL6
Comment All WT and mutant forms (A30P, A53T, and E46K) of alpha-synuclein stimulate human astrocytes as well as human U373MG astrocytoma cells to up-regulate the inflammatory markers ICAM-1 and IL-6. The mutant forms were more potent then WT-alpha-synuclein.
Formal Description
Interaction-ID: 8128

gene/protein mutant

SNCA-p.A53T

increases_quantity of

gene/protein

IL6

in astrocytes; more efficiently than WT-alpha-synuclein
Drugbank entries Show/Hide entries for IL6
Comment Alpha-synuclein induces phosphorylation of MAP kinases ERK1/2, p38MAPK and JNK.
Formal Description
Interaction-ID: 8138

gene/protein

SNCA

increases_phosphorylation of

gene/protein

MAPK3

Drugbank entries Show/Hide entries for MAPK3
Comment Alpha-synuclein induces phosphorylation of MAP kinases ERK1/2, p38MAPK and JNK.
Formal Description
Interaction-ID: 8139

gene/protein

SNCA

increases_phosphorylation of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for MAPK1
Comment Alpha-synuclein induces phosphorylation of MAP kinases ERK1/2, p38MAPK and JNK.
Formal Description
Interaction-ID: 8140

gene/protein

SNCA

increases_phosphorylation of

gene/protein

p38 MAPK

Comment Alpha-synuclein induces phosphorylation of MAP kinases ERK1/2, p38MAPK and JNK.
Formal Description
Interaction-ID: 8141

gene/protein

SNCA

increases_phosphorylation of

gene/protein

MAPK8

Drugbank entries Show/Hide entries for MAPK8
Comment Alpha-synuclein induces phosphorylation of MAP kinases ERK1/2, p38MAPK and JNK.
Formal Description
Interaction-ID: 8142

gene/protein

SNCA

increases_activity of

gene/protein

MAPK3

Drugbank entries Show/Hide entries for MAPK3
Comment Alpha-synuclein induces phosphorylation of MAP kinases ERK1/2, p38MAPK and JNK.
Formal Description
Interaction-ID: 8143

gene/protein

SNCA

increases_activity of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for MAPK1
Comment Alpha-synuclein induces phosphorylation of MAP kinases ERK1/2, p38MAPK and JNK.
Formal Description
Interaction-ID: 8145

gene/protein

SNCA

increases_activity of

gene/protein

p38 MAPK

Comment Alpha-synuclein induces phosphorylation of MAP kinases ERK1/2, p38MAPK and JNK.
Formal Description
Interaction-ID: 8146

gene/protein

SNCA

increases_activity of

gene/protein

MAPK8

Drugbank entries Show/Hide entries for MAPK8
Comment Increase of the inflammation markers, ICAM-1 and IL-6, after expression of alpha-synuclein is associated with activation of major mitogen-activated protein kinase (MAPK) pathways.
Formal Description
Interaction-ID: 8147

process

MAPK cascade

increases_quantity of

gene/protein

ICAM1

after addition of SNCA
Drugbank entries Show/Hide entries for ICAM1
Comment Increase of the inflammation markers, ICAM-1 and IL-6, after expression of alpha-synuclein is associated with activation of major mitogen-activated protein kinase (MAPK) pathways.
Formal Description
Interaction-ID: 8148

process

MAPK cascade

increases_quantity of

gene/protein

IL6

after addition of SNCA
Drugbank entries Show/Hide entries for IL6
Comment Increase of the inflammation markers, ICAM-1 and IL-6, after expression of alpha-synuclein is associated with activation of major mitogen-activated protein kinase (MAPK) pathways.
Formal Description
Interaction-ID: 8149

increases_quantity of

gene/protein

ICAM1

after addition of SNCA
Drugbank entries Show/Hide entries for ICAM1
Comment Increase of the inflammation markers, ICAM-1 and IL-6, after expression of alpha-synuclein is associated with activation of major mitogen-activated protein kinase (MAPK) pathways.
Formal Description
Interaction-ID: 8150

increases_quantity of

gene/protein

IL6

after addition of SNCA
Drugbank entries Show/Hide entries for IL6
Comment Increase of the inflammation markers, ICAM-1 and IL-6, after expression of alpha-synuclein is associated with activation of major mitogen-activated protein kinase (MAPK) pathways.
Formal Description
Interaction-ID: 8151

gene/protein

SNCA

increases_activity of

via ERK1/ERK2 phosphorylation
Comment Increase of the inflammation markers, ICAM-1 and IL-6, after expression of alpha-synuclein is associated with activation of major mitogen-activated protein kinase (MAPK) pathways.
Formal Description
Interaction-ID: 8152

gene/protein

SNCA

increases_activity of

via p38 MAPK phosphorylation
Comment Increase of the inflammation markers, ICAM-1 and IL-6, after expression of alpha-synuclein is associated with activation of major mitogen-activated protein kinase (MAPK) pathways.
Formal Description
Interaction-ID: 8157

gene/protein

SNCA

increases_activity of

process

JNK cascade

via p38 MAPK phosphorylation