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General Information:
Id:
1,209
Diseases:
Amyotrophic lateral sclerosis
Mus musculus
C57BL6/J mice
article
Reference:
Huang C et al.(2010) Sustained expression of TDP-43 and FUS in motor neurons in rodents lifetime Int. J. Biol. Sci. 6: 396-406
[PMID: 20616880]
Interaction Information:
Comment
The expression of the TDP-43 and FUS genes was robust and ubiquitous during postnatal development but was markedly decreased in adulthood. In contrast, sustainable levels of TDP-43 and FUS proteins were detected in mouse central nervous system (CNS) including brain, cerebellum, and spinal cord, implying that TDP-43 and FUS proteins are critical to neuron survival.
The expression of the TDP-43 and FUS genes was robust and ubiquitous during postnatal development but was markedly decreased in adulthood. In contrast, sustainable levels of TDP-43 and FUS proteins were detected in mouse central nervous system (CNS) including brain, cerebellum, and spinal cord, implying that TDP-43 and FUS proteins are critical to neuron survival.
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