General Information:

Id: 1,209 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
C57BL6/J mice
article
Reference: Huang C et al.(2010) Sustained expression of TDP-43 and FUS in motor neurons in rodents lifetime Int. J. Biol. Sci. 6: 396-406 [PMID: 20616880]

Interaction Information:

Comment The expression of the TDP-43 and FUS genes was robust and ubiquitous during postnatal development but was markedly decreased in adulthood. In contrast, sustainable levels of TDP-43 and FUS proteins were detected in mouse central nervous system (CNS) including brain, cerebellum, and spinal cord, implying that TDP-43 and FUS proteins are critical to neuron survival.
Formal Description
Interaction-ID: 8107

process

aging

decreases_quantity of

gene/protein

TARDBP