General Information:

Id: 1,209
Diseases: Amyotrophic lateral sclerosis
Mus musculus
C57BL6/J mice
article
Reference: Huang C et al.(2010) Sustained expression of TDP-43 and FUS in motor neurons in rodents lifetime Int. J. Biol. Sci. 6: 396-406 [PMID: 20616880]

Interaction Information:

Comment The expression of the TDP-43 and FUS genes was robust and ubiquitous during postnatal development but was markedly decreased in adulthood. In contrast, sustainable levels of TDP-43 and FUS proteins were detected in mouse central nervous system (CNS) including brain, cerebellum, and spinal cord, implying that TDP-43 and FUS proteins are critical to neuron survival.
Formal Description
Interaction-ID: 8107

process

aging

decreases_quantity of

gene/protein

TARDBP

Comment The expression of the TDP-43 and FUS genes was robust and ubiquitous during postnatal development but was markedly decreased in adulthood. In contrast, sustainable levels of TDP-43 and FUS proteins were detected in mouse central nervous system (CNS) including brain, cerebellum, and spinal cord, implying that TDP-43 and FUS proteins are critical to neuron survival.
Formal Description
Interaction-ID: 8111

process

aging

decreases_quantity of

gene/protein

FUS

Comment Motor neurons expressed the TDP-43 and the FUS genes at robust levels throughout rodent's (mice and rats) lifetime.
Formal Description
Interaction-ID: 8112

process

aging

NOT decreases_quantity of

gene/protein

TARDBP

in motor neurons
Comment Motor neurons expressed the TDP-43 and the FUS genes at robust levels throughout rodent's (mice and rats) lifetime.
Formal Description
Interaction-ID: 8113

process

aging

NOT decreases_quantity of

gene/protein

FUS

in motor neurons