General Information:

Id: 1,207 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Lumeng CN et al.(2007) Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity Diabetes 56: 16-23 [PMID: 17192460]

Interaction Information:

Comment Although CD14 and TNF-alpha were expressed at equal levels in resident and recruited adipose tissue macrophage (ATM) pools, IL-6, iNOS, and CCR2 were expressed at higher levels in the recruited ATMs. Expression of these inflammatory genes in both recruited and resident high-fat diet ATM populations were higher than ATMs from normal diet mice. This suggests that ATMs newly recruited to adipose tissue have an increased inflammatory capacity compared with resident ATMs.
Formal Description
Interaction-ID: 8095

tissue/cell line

recruited adipose tissue macrophage

affects_expression of

gene/protein

IL6

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