General Information:

Id: 1,204
Diseases: Parkinson disease
Mus musculus
SNCA-inducible transgenic mice in which the PD-related A53T-SNCA is selectively expressed by astrocytes
BTO:0000099 astrocyte
article
Reference: Gu XL et al.(2010) Astrocytic expression of Parkinsons disease-related A53T alpha-synuclein causes neurodegeneration in mice Mol Brain 3: 12 [PMID: 20409326]

Interaction Information:

Comment The A53T transgenic mice developed an early onset rapidly progressed movement disability.
Formal Description
Interaction-ID: 8075

gene/protein mutant

SNCA-p.A53T

increases_activity of

Comment Astrocytic expression of A53T-SNCA induced widespread astrogliosis.
Formal Description
Interaction-ID: 8082

gene/protein mutant

SNCA-p.A53T

increases_activity of

in brain
Comment The processes of astrocyte end-feet encircle the endothelial cell of blood vessels for maintenance of blood-brain barrier.
Formal Description
Interaction-ID: 8084

tissue/cell line

astrocyte

increases_activity of

Comment Astrocytic expression of A53T-SNCA disrupted the blood-brain barrier.
Formal Description
Interaction-ID: 8087

gene/protein mutant

SNCA-p.A53T

decreases_activity of

Comment Astrocytic expression of A53T-SNCA induced activation of microglia in the CNS.
Formal Description
Interaction-ID: 8088

gene/protein mutant

SNCA-p.A53T

increases_activity of

Comment Activated microglia may play an important role in triggering the loss of neuron.
Formal Description
Interaction-ID: 8091

increases_activity of

process

neuron death

Comment Expression level of cyclooxygenase-1 (COX-1), which expression is restricted to microglia, was also up-regulated in the brainstem of symptomatic A53T mice; while the expression level of neuron-enriched COX-2 was not affected.
Formal Description
Interaction-ID: 8092

gene/protein mutant

SNCA-p.A53T

increases_expression of

gene/protein

PTGS1

in microglia
Drugbank entries Show/Hide entries for PTGS1
Comment Expression level of cyclooxygenase-1 (COX-1), which expression is restricted to microglia, was also up-regulated in the brainstem of symptomatic A53T mice; while the expression level of neuron-enriched COX-2 was not affected.
Formal Description
Interaction-ID: 8093

gene/protein mutant

SNCA-p.A53T

NOT increases_expression of

gene/protein

PTGS2

in microglia
Drugbank entries Show/Hide entries for PTGS2
Comment Treatment of A53T-mice with SC-560, a selective inhibitor of COX-1, increased the lifespan of these animals, suggesting that microglia-mediated inflammatory responses directly contribute to the neurodegeneration in A53T mice.
Formal Description
Interaction-ID: 8096

gene/protein

MT-CO1

increases_activity of

process

neuron death

Drugbank entries Show/Hide entries for MT-CO1
Comment Treatment of A53T-mice with SC-560, a selective inhibitor of COX-1, increased the lifespan of these animals, suggesting that microglia-mediated inflammatory responses directly contribute to the neurodegeneration in A53T mice.
Formal Description
Interaction-ID: 8097

drug/chemical compound

SC-560

decreases_activity of

process

neuron death

Comment Treatment of A53T-mice with SC-560, a selective inhibitor of COX-1, increased the lifespan of these animals, suggesting that microglia-mediated inflammatory responses directly contribute to the neurodegeneration in A53T mice.
Formal Description
Interaction-ID: 8098

gene/protein mutant

SNCA-p.A53T

increases_activity of

process

neuron death

via microglia-mediated inflammatory responses
Comment Treatment of A53T-mice with SC-560, a selective inhibitor of COX-1, increased the lifespan of these animals, suggesting that microglia-mediated inflammatory responses directly contribute to the neurodegeneration in A53T mice.
Formal Description
Interaction-ID: 8099

drug/chemical compound

SC-560

decreases_activity of

gene/protein

PTGS1

Drugbank entries Show/Hide entries for PTGS1
Comment A significant increase of TNF-alpha, IL-1beta, and IL-6 expression was observed in the brainstem but not in the cerebral cortex of A53T mice.
Formal Description
Interaction-ID: 8100

gene/protein mutant

SNCA-p.A53T

increases_expression of

gene/protein

TNF

in the brainstem but not in the cerebral cortex of A53T mice
Drugbank entries Show/Hide entries for TNF
Comment A significant increase of TNF-alpha, IL-1beta, and IL-6 expression was observed in the brainstem but not in the cerebral cortex of A53T mice.
Formal Description
Interaction-ID: 8101

gene/protein mutant

SNCA-p.A53T

increases_expression of

gene/protein

IL1B

in the brainstem but not in the cerebral cortex of A53T mice
Drugbank entries Show/Hide entries for IL1B
Comment A significant increase of TNF-alpha, IL-1beta, and IL-6 expression was observed in the brainstem but not in the cerebral cortex of A53T mice.
Formal Description
Interaction-ID: 8102

gene/protein mutant

SNCA-p.A53T

increases_expression of

gene/protein

IL6

in the brainstem but not in the cerebral cortex of A53T mice
Drugbank entries Show/Hide entries for IL6