General Information:

Id: 1,203 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
article
Reference: Weisberg SP et al.(2006) CCR2 modulates inflammatory and metabolic effects of high-fat feeding J. Clin. Invest. 116: 115-124 [PMID: 16341265]

Interaction Information:

Comment IL-6 and PAI-1 are circulating proteins that are produced by multiple organs and tissues including adipose tissue, liver, leukocytes, and endothelial cells. Both have been implicated in obesity-induced insulin resistance, and the adipose tissue expression of both is increased in obesity. No Ccr2-dependent modulation in adipose tissue expression of IL-6 or PAI-1 was detected.
Formal Description
Interaction-ID: 8071

gene/protein

CCR2

NOT affects_expression of

gene/protein

IL6

in adipose tissue
Drugbank entries Show/Hide entries for IL6
Comment Consistent with the gene expression data, there were no CCR2-dependent alterations in the circulating concentration of IL-6. In contrast, lower circulating concentrations of PAI-1 in lean and obese Ccr2-/- mice were detected when compared with weightmatched Ccr2+/+ mice. These data reveal that CCR2 modulates circulating PAI-1 by a mechanism that is not primarily dependent upon adipose tissue expression or the development of obesity.
Formal Description
Interaction-ID: 8073

gene/protein

CCR2

NOT affects_quantity of

gene/protein

IL6

in blood
Drugbank entries Show/Hide entries for IL6