CIDeRGeneral Information:
| Id: | 1,203 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
| Mus musculus | |
| male | |
| article | |
| Reference: | Weisberg SP et al.(2006) CCR2 modulates inflammatory and metabolic effects of high-fat feeding J. Clin. Invest. 116: 115-124 [PMID: 16341265] |
Interaction Information:
| Comment | IL-6 and PAI-1 are circulating proteins that are produced by multiple organs and tissues including adipose tissue, liver, leukocytes, and endothelial cells. Both have been implicated in obesity-induced insulin resistance, and the adipose tissue expression of both is increased in obesity. No Ccr2-dependent modulation in adipose tissue expression of IL-6 or PAI-1 was detected. |
|
Formal Description Interaction-ID: 8071 |
|
| Drugbank entries | Show/Hide entries for IL6 |
| Comment | Consistent with the gene expression data, there were no CCR2-dependent alterations in the circulating concentration of IL-6. In contrast, lower circulating concentrations of PAI-1 in lean and obese Ccr2-/- mice were detected when compared with weightmatched Ccr2+/+ mice. These data reveal that CCR2 modulates circulating PAI-1 by a mechanism that is not primarily dependent upon adipose tissue expression or the development of obesity. |
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Formal Description Interaction-ID: 8073 |
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| Drugbank entries | Show/Hide entries for IL6 |