General Information:

Id: 1,203 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
article
Reference: Weisberg SP et al.(2006) CCR2 modulates inflammatory and metabolic effects of high-fat feeding J. Clin. Invest. 116: 115-124 [PMID: 16341265]

Interaction Information:

Comment Several individual genes with higher levels of expression in Ccr2-/- than in Ccr2+/+ obese mice encode hormones produced by adipocytes, including leptin (Lep), resistin (Retn), and adiponectin (Acdc).
Formal Description
Interaction-ID: 8064

gene/protein

CCR2

affects_expression of

gene/protein

LEP

in adipose tissue; in obese mice
Comment Despite alterations in adipose tissue gene expression, no differences in circulating concentrations of leptin or resistin were detected between obese Ccr2-/- and Ccr2+/+ mice.
Formal Description
Interaction-ID: 8067

gene/protein

CCR2

NOT affects_quantity of

gene/protein

LEP

in blood; in obese mice