General Information:

Id: 1,202 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Arkan MC et al.(2005) IKK-beta links inflammation to obesity-induced insulin resistance Nat. Med. 11: 191-198 [PMID: 15685170]

Interaction Information:

Comment mRNAs encoding IL-1alpha, IL-1beta, IL-6 and RANTES were elevated in livers from Ikbkb F/F mice (homozygous for the nondeleted Ikbkb allele flanked by 10xP sites) on high fat diet. This increase was markedly attenuated in Ikbkb-Delta-hep mice (mice lacking Ikbkb in hepatocytes).
Formal Description
Interaction-ID: 8026

environment

high-fat diet

increases_expression of

gene/protein

IL6

in liver; in Ikbkb F/F mice
Drugbank entries Show/Hide entries for IL6