General Information:

Id: 11
Diseases: Parkinson disease
Mus musculus
primary cortical neurons
article
Reference: Smith WW et al.(2005) Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc. Natl. Acad. Sci. U.S.A. 102 [PMID: 16352719]

Interaction Information:

Comment Transfection of LRRK2 into primary cortical neuronal cultures does not significantly alter cell viability.
Formal Description
Interaction-ID: 33

gene/protein

LRRK2

NOT increases_activity of

process

neuron death

Comment Transfection of LRRK2 mutants R1441C, Y1699C or G2019S into primary cortical neuronal cultures leads to cell death.
Formal Description
Interaction-ID: 34

gene/protein mutant

LRRK2-p.R1441C

increases_activity of

process

neuron death

Comment Transfection of LRRK2 mutants R1441C, Y1699C or G2019S into primary cortical neuronal cultures does not significantly alter cell viability.
Formal Description
Interaction-ID: 35

gene/protein mutant

LRRK2-p.Y1699C

increases_activity of

process

neuron death

Comment Transfection of LRRK2 mutants R1441C, Y1699C or G2019S into primary cortical neuronal cultures does not significantly alter cell viability.
Formal Description
Interaction-ID: 36

gene/protein mutant

LRRK2-p.G2019S

increases_activity of

process

neuron death