General Information:

Id: 119 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
NSC34 cells, expressing SOD1(G93A) or SOD1(G85R)
BTO:0004488 NSC-34 cell; BTO:0000312 motoneuron
article
Reference: Hetz C et al.(2009) XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy Genes Dev. 23: 2294-2306 [PMID: 19762508]

Interaction Information:

Comment XBP-1 deficiency leads to autophagy-mediated degradation of mutant SOD1. LC3 is a commonly used marker of autophagy that localizes specifically to autophagosomes. Using LC3-EGFP fusion to determine autophagosome content, a clear increase in the number of shXBP-1 (XBP-1 knockdown) cells containing autophagosomes was observed, compared with control cells.
Formal Description
Interaction-ID: 5054

gene/protein

XBP1

affects_activity of

process

autophagy